Messi has missed PSG’s past two games but the 34-year-old has overcome a knee injury and starts at the Parc des Princes.
Two of the favourites for this season’s Champions League meet in this crucial Group A clash.
PSG cannot afford to let more points in the competition slip after a surprise opening draw to Club Brugge.
City started their European campaign with an entertaining 6-3 win over RB Leipzig and travel to Paris with their confidence boosted after a superb, controlled win over Premier League leaders Chelsea at Stamford Bridge.
The pair last met at the semi-final stage of last year’s competition, with Manchester City victorious in both legs on their way to a 4-1 aggregate triumph.
Date, kick-off time and venue
PSG vs Manchester City is scheduled for a 8pm BST kick-off at the Parc des Princes in Paris.
Where to watch PSG vs Manchester City
TV channel: Tonight’s match will be televised on BT Sport 2, with coverage starting at 7pm.
Live stream: BT Sport subscribers will be able to watch the match via the BT Sport app or website.
PSG vs Manchester City lineups and team news
PSG XI: Donnarumma; Hakimi, Marquinhos, Kimpembe, Nuno Mendes; Ander Herrera, Verratti, Gueye; Messi, Mbappé, Neymar.
Subs: Navas, Letellier, Paredes, Icardi, Danilo, Dagba, Wijnaldum, Kurzawa, Diallo, Draxler, Kehrer, Dina Ebimbe.
Man City XI: Ederson, Walker, Dias, Laporte, Cancelo, Rodri, De Bruyne, Bernardo, Grealish, Mahrez, Sterling
Subs: Steffen, Carson, Stones, Ake, Wilson-Esbrand, Fernandinho, Foden, McAtee, Torres, Jesus
How to watch and odds
- Date: Tuesday, Sept. 28 | Time: 3 p.m. ET
- Location: Parc des Princes — Paris, France
- TV and Live stream: Paramount+
- Odds: PSG +200; Draw +255; City +129 (via Caesars Sportsbook)